My scientific interest is mainly about the mechanisms of cell fate determination, especially in stem cells and cancer cells. I am curious about how the potency of differentiation is maintained in stem cells and what factors play major roles in particular cell lines. In order to fulfill this goal, quite a few technologies will be utilized such as SELEX-seq, ChIP-Seq, RNA-Seq, DNase I hypersensitivity assays and so on. With the help of these high throughput methods in the lab, I will study the interactions between transcription factors and the gene regulatory regions within the genome, trying to decipher the master transcription factors crucial for different cell fates. Furthermore, by looking through the results, we should understand the plasticity of the genome in the cells at a molecular level and finally we can obtain a clearer picture of the mechanisms of cell fate determination.
Bei Wei
