My interest is focused on the transcriptional regulation of growth control and lineage specification with emphasis on the question of how these are tweaked to generate a cancerous cell. Based on our analysis of the Myc-335 enhancer we postulate that a cancer cell might rely on cancer-specific transcriptional switches (enhancers) for its growth. A comprehensive identification and understanding of these would be useful in designing targeted therapy against cancer cells. Towards this goal I am currently studying- 1) the contribution of enhancer elements upstream of c-MYC to cancerous growth using in vivo models and 2) function of transcription factor Klf5 in cellular fate specifications.
Inderpreet Sur
