Growth signals are transmitted by diverse and redundant mechanisms. This redundancy is needed for tissue specific regulation of cell growth, but also makes it challenging to block growth signalling in cancer cells. Although signal transduction has been studied a lot, it is inadequately understood how the growth signal pathways interface with conserved processes of cell growth. My aim is to identify and characterize common dependencies of proliferating cancer cells. To achieve this, I am manipulating proliferation and pathway usage in different cancer cell types, and collecting data using phosphoproteomics, thermal proteome profiling, single-cell RNAseq, and targeted genome editing based dropout screens.
Otto Kauko
